| ncRNA name | hsa-miR-101 |
| ncRNA Category | miRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | RB samples, normal retinas; RB cell lines SO-RB50, Y79 and WERI-RB1; RPE cell line ARPE-19 |
| Methods | transfection, CCK-8 assay, transwell assay, flow cytometry, luciferase reporter assay, RNA immunoprecipitation (RIP), qPCR, in situ hybridization, Western blot |
| Expression pattern | down-regulated |
| Functional description | We found the expression of XIST, ZEB1 and ZEB2 was increased, whereas miR-101 was reduced in RB tissues and cells. We found that XIST functioned as a competing endogenous RNA (ceRNA) for miR-101 to regulate the de-repression of its endogenous targets ZEB1 and ZEB2. |
| PubMed ID | 30472203 |
| Year | 2019 |
| Title | LncRNA XIST promotes the epithelial to mesenchymal transition of retinoblastoma via sponging miR-101. |
| Drug-related ncRNA | NO |
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